Product of the normal gene homologue of v- akt, the transforming oncogene of AKT8 virus. A serine/threonine kinase (58 kD) with SH2 and PH domains, activated by PI3kinase downstream of insulin and other growth factor receptors. AKT will phosphorylate GSK3 and is involved in stimulation of Ras and control of cell survival. Three members of the Akt/PKB family have been identified, Akt/PKB a, AKT2/PKB b, AKT3/PKB g. Only AKT2 has been shown to be involved in human malignancy.
Dictionary of molecular biology. 2004.